Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects.

doi:10.1111/j.1365-2125.1990.tb03687.x

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Article

Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects.

British journal of clinical pharmacology - 1 Jun 1990

Schellens J H, van der Wart J H, Breimer D D

Abstract excerpt

1. In a phenotyped panel of healthy subjects correlations were studied between the oxidation of mephenytoin, phenytoin, methylphenytoin and phenobarbitone, with respect to the formation of their 4-hydroxy metabolites (OH-). 2. On different occasions phenotyped extensive metabolizers (EM; n = 16)...

Topics

Adult
Female
Humans
Hydantoins
Hydroxylation
Male
Mephenytoin
Oxidation-Reduction
Phenobarbital
Phenotype
Phenytoin

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