Article
Sparteine and mephenytoin oxidation: genetic polymorphisms in east and west Greenland.
Clinical pharmacology and therapeutics - 1 Jun 1991
Clasen K, Madsen L, Brøsen K, Albøge K, Misfeldt S, Gram L F
Abstract excerpt
The oxidation of sparteine and mephenytoin was examined in a group of subjects living in Greenland: 300 in East Greenland and 171 in West Greenland. The distribution of the ratio between the chromatographic peak areas of S- and R-mephenytoin in the urine, the S/R ratio was clearly bimodal in both...
Topics
- Adolescent
- Adult
- Aged
- Female
- Genetic Variation
- Greenland
- Humans
- Male
- Mephenytoin
- Middle Aged
- Oxidation-Reduction
- Polymorphism, Genetic
- Population
- Sparteine
- White People