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Article

S-mephenytoin hydroxylation phenotypes in a Jordanian population.

Clinical pharmacology and therapeutics - 1 Nov 1995

Hadidi H F, Irshaid Y M, Woosley R L, Idle J R, Flockhart D A

Abstract excerpt

We tested the ability of 194 unrelated, healthy Jordanian volunteers to metabolize S-mephenytoin. Mephenytoin (100 mg) was coadministered with debrisoquin (10 mg) orally and urine was collected for 8 hours. Mephenytoin metabolism was tested according to three measures: the amount of 4-hydroxymephenytoin, the S/R enantiomeric ratio, and the presence of a polar, acid-labile metabolite in urine collected for 8 hours...

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Source

Identifiers

PMID: 7586948
DOI: 10.1016/0009-9236(95)90174-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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