Article
A multifamily study on the relationship between CYP2C19 genotype and s-mephenytoin oxidation phenotype.
Pharmacogenetics - 1 Oct 1995
Brøsen K, de Morais S M, Meyer U A, Goldstein J A
Abstract excerpt
It has recently been shown that the most common mutation (named m1) in both Caucasian and Japanese poor metabolizers (PM) of S-mephenytoin is a single base pair mutation (G-->A) in exon 5 of the CYP2C19 gene. In Japanese, a second defective allele of CYP2C19 named m2 consists of a G-->A mutation in exon 4. In the present study, we have investigated the inheritance of the CYP2C19 wild type allele (wt) and the two...
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