Frequency of S-mephenytoin hydroxylation deficiency in 373 Spanish subjects compared to other Caucasian populations.

doi:10.1007/BF02440867

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Article

Frequency of S-mephenytoin hydroxylation deficiency in 373 Spanish subjects compared to other Caucasian populations.

European journal of clinical pharmacology - 1 Jan 1993

Reviriego J, Bertilsson L, Carrillo J A, Llerena A, Valdivielso M J, Benítez J

Abstract excerpt

We have investigated the prevalence of poor metabolisers (PM) of S-mephenytoin in 373 unrelated, healthy Spanish Caucasian subjects, based on the enantiomeric S/R mephenytoin ratio in urine collected 0-8 h and 24-32 h after intake of the racemic drug. Five of the subjects were PM (1.34%, 95% confidence interval 0.18-2.59%), a prevalence lower than in 6 other Caucasian populations, but only significantly lower...

Topics

Adolescent
Adult
Aged
Female
Humans
Hydroxylation
Male
Mephenytoin
Middle Aged
Phenotype
Spain
Stereoisomerism
White People

Source

Open in PubMed

Identifiers

PMID: 8405020
DOI: 10.1007/BF02440867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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