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Article

Concerted kinetic folding of a multidomain ribozyme with a disrupted loop-receptor interaction.

Journal of molecular biology - 5 Jan 2001

Treiber D K, Williamson J R

Abstract excerpt

The free energy landscape for the folding of large, multidomain RNAs is rugged, and kinetically trapped, misfolded intermediates are a hallmark of RNA folding reactions. Here, we examine the role of a native loop-receptor interaction in determining the ruggedness of the energy landscape for folding of the Tetrahymena ribozyme. We demonstrate a progressive smoothing of the energy landscape for ribozyme folding as...

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Identifiers

PMID: 11114243
DOI: 10.1006/jmbi.2000.4253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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