Article
Gastric adenocarcinoma and Helicobacter pylori: correlation with p53 mutation and p27 immunoexpression.
Cancer epidemiology - 1 Oct 2010
André Angela Rosa, Ferreira Márcia Valéria Pitombeira, Mota Rosa Maria Salani, Ferrasi Adriana Camargo, Pardini Maria Inês de Moura Campos, Rabenhorst Sílvia Helena Barem
Abstract excerpt
INTRODUCTION: Helicobacter pylori infection is an established risk factor for gastric cancer development, but the exact underlying mechanism still remains obscure. The inactivation of tumor suppressor genes such as p53 and p27(KIP1) is a hypothesized mechanism, although there is no consensus regarding the influence of H. pylori cagA(+) in the development of these genetic alterations. GOALS: To verify the...
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