Pathogenic bacterium <i>Helicobacter pylori</i> alters the expression profile of p53 protein isoforms and p53 response to cellular stresses

Abstract excerpt

The p53 protein plays a central role in the prevention of tumorigenesis. Cellular stresses, such as DNA damage and aberrant oncogene activation, trigger induction of p53 that halts cellular proliferation and allows cells to be repaired. If cellular damage is beyond the capability of the repair mechanisms, p53 induces apoptosis or cell cycle arrest, preventing damaged cells from becoming cancerous. However,...

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