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Article

p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice.

Gastroenterology - 1 Nov 2005

Kuzushita Noriyoshi, Rogers Arlin B, Monti Nola A, Whary Mark T, Park Min J, Aswad Bassam I, Shirin Haim, Koff Andrew, Eguchi Hidetoshi, Moss Steven F

Abstract excerpt

BACKGROUND & AIMS: Determining how Helicobacter pylori promotes gastric cancer and whether H pylori eradication decreases cancer risk would be helped by suitable murine models. Mice lacking the cyclin-dependent kinase inhibitor p27kip1 are susceptible to carcinogen-induced tumors. Furthermore, p27 stimulates gastric epithelial apoptosis and inhibits proliferation, expression is decreased by H pylori, and low...

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Identifiers

PMID: 16285954
DOI: 10.1053/j.gastro.2005.07.056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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