Article
Severity of atrophic gastritis related to antiparietal cell antibody and gastric carcinogenesis, including p53 mutations.
Journal of gastroenterology and hepatology - 1 Mar 2006
Taguchi Ayumu, Ohmiya Naoki, Itoh Akihiro, Hirooka Yoshiki, Niwa Yasumasa, Mori Naoyoshi, Goto Hidemi
Abstract excerpt
BACKGROUND AND AIMS: Infection with Helicobacter pylori (Hp) has been linked to atrophic gastritis, an inflammatory precursor of non-cardia gastric carcinoma. Mutations in the p53 gene are one of the most frequent genetic alterations in gastric carcinoma. In a subgroup of atrophic gastritis, antiparietal cell antibody (APCA) has been detected. This study was aimed to clarify the role of APCA in the progression of...
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