Article
Unequal distribution of resistance-conferring mutations among Mycobacterium tuberculosis and Mycobacterium africanum strains from Ghana.
International journal of medical microbiology : IJMM - 1 Nov 2010
Homolka Susanne, Meyer Christian G, Hillemann Doris, Owusu-Dabo Ellis, Adjei Ohene, Horstmann Rolf D, Browne Edmund N L, Chinbuah Amanua, Osei Ivy, Gyapong John, Kubica Tanja, Ruesch-Gerdes Sabine, Niemann Stefan
Abstract excerpt
Isoniazid (INH) and rifampicin (RMP) resistance in Mycobacterium tuberculosis complex (MTC) isolates are mainly based on mutations in a limited number of genes. However, mutation frequencies vary in different mycobacterial populations. In this work, we analyzed the distribution of resistance-associated mutations in M. tuberculosis and M. africanum strains from Ghana, West Africa. The distribution of mutations in...
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