Article
Detection and characterization of drug-resistant conferring genes in Mycobacterium tuberculosis complex strains: A prospective study in two distant regions of Ghana.
Tuberculosis (Edinburgh, Scotland) - 1 Jul 2016
Otchere I D, Asante-Poku A, Osei-Wusu S, Baddoo A, Sarpong E, Ganiyu A H, Aboagye S Y, Forson A, Bonsu F, Yahayah A I, Koram K, Gagneux S, Yeboah-Manu D
Abstract excerpt
We spoligotyped and screened 1490 clinical Mycobacterium tuberculosis complex strains from Northern and Greater Accra regions of Ghana against INH and RIF using the microplate alamar blue phenotypic assay. Specific drug resistance associated genetic elements of drug resistant strains were analyzed for mutations. A total of 111 (7.5%), 10 (0.7%) and 40 (2.6%) were mono-resistant to INH, RIF, and MDR, respectively....
Topics
- Antitubercular Agents
- Bacterial Proteins
- DNA Mutational Analysis
- Drug Resistance, Multiple, Bacterial
- Female
- Genotype
- Ghana
- Humans
- Male
- Microbial Sensitivity Tests