Article
Prevalence of katG and inhA mutations associated with isoniazid resistance in Mycobacterium tuberculosis clinical isolates in Cameroon.
BMC microbiology - 10 Mar 2025
Nono Vanessa Ninkeh, Nantia Edouard Akono, Mutshembele Awelani, Teagho Sorelle Nguimfack, Simo Yannick Willy Kamdem, Takong Brenda Shile, Djieugoue Yvonne Josiane, Assolo Yannick Patrick, Ongboulal Suzanne Magloire, Awungafac Stanley Nkemnji, Eyangoh Sara, Mensah Eric, Makhado Ndivhuho Agnes, Donfack Valerie Flore Donkeng
Abstract excerpt
BACKGROUND: The acquisition of isoniazid (INH) resistance is alarming, considering its importance as a key drug that forms the core of multidrug treatment regimens for tuberculosis (TB). Genetic mutations in the katG and inhA promoter regions play crucial roles in INH resistance, but their prevalence varies geographically. This study aimed to identify the most common mutations in the katG and inhA genes in...
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