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Article

Population robustness arising from cellular heterogeneity.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010

Paszek Pawel, Ryan Sheila, Ashall Louise, Sillitoe Kate, Harper Claire V, Spiller David G, Rand David A, White Michael R H

Abstract excerpt

Heterogeneity between individual cells is a common feature of dynamic cellular processes, including signaling, transcription, and cell fate; yet the overall tissue level physiological phenotype needs to be carefully controlled to avoid fluctuations. Here we show that in the NF-kappaB signaling system, the precise timing of a dual-delayed negative feedback motif [involving stochastic transcription of inhibitor...

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Identifiers

PMID: 20534546
DOI: 10.1073/pnas.0913798107
PMCID: PMC2895068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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