Article
Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.
Cell systems - 26 Apr 2017
Martins Andrew J, Narayanan Manikandan, Prüstel Thorsten, Fixsen Bethany, Park Kyemyung, Gottschalk Rachel A, Lu Yong, Andrews-Pfannkoch Cynthia, Lau William W, Wendelsdorf Katherine V, Tsang John S
Abstract excerpt
Cell-to-cell variation in gene expression and the propagation of such variation (PoV or "noise propagation") from one gene to another in the gene network, as reflected by gene-gene correlation across single cells, are commonly observed in single-cell transcriptomic studies and can shape the phenotypic diversity of cell populations. While gene network "rewiring" is known to accompany cellular adaptation to...
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