Statistical ensemble analysis for simulating extrinsic noise-driven response in NF-κB signaling networks.

Abstract excerpt

BACKGROUND: Gene expression profiles and protein dynamics in single cells have a large cell-to-cell variability due to intracellular noise. Intracellular fluctuations originate from two sources: intrinsic noise due to the probabilistic nature of biochemical reactions and extrinsic noise due to randomized interactions of the cell with other cellular systems or its environment. Presently, there is no systematic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computational Biology
• Share to Gene Knockout Techniques
• Share to I-kappa B Kinase