Article

A computational workflow for assessing drug effects on temporal signaling dynamics reveals robustness in stimulus-specific NFκB signaling

2025-04-02

Abstract excerpt

Single-cell studies of signal transduction have revealed complex temporal dynamics that determine downstream biological function. For example, the stimulus-specific dynamics of the transcription factor NFκB specify stimulus-specific gene expression programs, and loss of specificity leads to disease. Thus, it is intriguing to consider drugs that may restore signaling specificity in disease contexts, or reduce activ...

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Literature Corpus work: 3734a952-c6e1-5d6a-b936-224fabe63a87
DOI: 10.1101/2025.03.31.645599

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