Article
Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations.
PloS one - 1 Jun 2010
Perez Laurent-Herve, Butler Matt, Creasey Tammy, Dzink-Fox JoAnn, Gounarides John, Petit Stephanie, Ropenga Anna, Ryder Neil, Smith Kathryn, Smith Philip, Parkinson Scott J
Abstract excerpt
BACKGROUND: A homeostatic relationship with the intestinal microflora is increasingly appreciated as essential for human health and wellbeing. Mutations in the leucine-rich repeat (LRR) domain of Nod2, a bacterial recognition protein, are associated with development of the inflammatory bowel disorder, Crohn's disease. We investigated the molecular mechanisms underlying disruption of intestinal symbiosis in...
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