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Article

NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease.

European journal of immunology - 1 Jul 2004

Netea Mihai G, Kullberg Bart Jan, de Jong Dirk J, Franke Barbara, Sprong Tom, Naber Ton H J, Drenth Joost P H, Van der Meer Jos W M

Abstract excerpt

Mutations of the NOD2 gene have been associated with an increased susceptibility to Crohn's disease, but the pathogenetic mechanisms mediated by NOD2 remain elusive. In the present study, we demonstrate that the 3020insC frameshift-mutation in the NOD2 gene associated with Crohn's disease results...

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Source

Identifiers

PMID: 15214053
DOI: 10.1002/eji.200425229

Genes

NOD2
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15214053-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease.PMID 15214053Read ↗

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