Article
Clustering phenotype populations by genome-wide RNAi and multiparametric imaging.
Molecular systems biology - 8 Jun 2010
Fuchs Florian, Pau Gregoire, Kranz Dominique, Sklyar Oleg, Budjan Christoph, Steinbrink Sandra, Horn Thomas, Pedal Angelika, Huber Wolfgang, Boutros Michael
Abstract excerpt
Genetic screens for phenotypic similarity have made key contributions to associating genes with biological processes. With RNA interference (RNAi), highly parallel phenotyping of loss-of-function effects in cells has become feasible. One of the current challenges however is the computational categorization of visual phenotypes and the prediction of biological function and processes. In this study, we describe a...
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