Article
A global genetic interaction network by single-cell imaging and machine learning.
Cell systems - 17 May 2023
Heigwer Florian, Scheeder Christian, Bageritz Josephine, Yousefian Schayan, Rauscher Benedikt, Laufer Christina, Beneyto-Calabuig Sergi, Funk Maja Christina, Peters Vera, Boulougouri Maria, Bilanovic Jana, Miersch Thilo, Schmitt Barbara, Blass Claudia, Port Fillip, Boutros Michael
Abstract excerpt
Cellular and organismal phenotypes are controlled by complex gene regulatory networks. However, reference maps of gene function are still scarce across different organisms. Here, we generated synthetic genetic interaction and cell morphology profiles of more than 6,800 genes in cultured Drosophila cells. The resulting map of genetic interactions was used for machine learning-based gene function discovery,...
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