Article
Alloreactive T cells discriminate among a diverse set of endogenous peptides.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991
Heath W R, Kane K P, Mescher M F, Sherman L A
Abstract excerpt
Previous studies have demonstrated that class I major histocompatibility complex (MHC) molecules are occupied by peptides of endogenously synthesized self proteins. Since graft rejection appears to be mediated by the normal occurrence of high frequencies of cytolytic T lymphocytes (CTLs) specific for allogeneic MHC molecules, it is important to know if such CTLs recognize specific MHC-peptide complexes (as...
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