Article
Alloreactive T cells discriminate among a diverse set of endogenous peptides.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1991
Heath W R, Kane K P, Mescher M F, Sherman L A
Abstract excerpt
Previous studies have demonstrated that class I major histocompatibility complex (MHC) molecules are occupied by peptides of endogenously synthesized self proteins. Since graft rejection appears to be mediated by the normal occurrence of high frequencies of cytolytic T lymphocytes (CTLs) specific...
Topics
- Animals
- Cell Line
- Chromatography, High Pressure Liquid
- Cyanogen Bromide
- Genes, MHC Class I
- Humans
- Major Histocompatibility Complex
- Mice
- Mutation
- Peptides
- Substrate Specificity
- T-Lymphocytes, Cytotoxic