Article
Homology between an alloantigen and a self MHC allele calibrates the avidity of the alloreactive T cell repertoire independent of TCR affinity.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2003
Hornell Tara M C, Myers Nancy, Hansen Ted H, Connolly Janet M
Abstract excerpt
The self-restricted T cell repertoire exhibits a high frequency of alloreactivity. Because these alloreactive T cells are derived from the pool of cells selected on several different self MHC alleles, it is unknown how development of the alloantigenic repertoire is influenced by homology between a self MHC allele and an alloantigen. To address this, we used the 2C transgenic TCR that is selected by K(b), is...
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