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Article

Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis in critically ill patients.

The Journal of international medical research - 1 Feb 2014

Nachtigall Irit, Tamarkin Andrey, Tafelski Sascha, Weimann Andreas, Rothbart Andreas, Heim Susanne, Wernecke Klaus D, Spies Claudia

Abstract excerpt

OBJECTIVE: To determine whether the Arg753Gln polymorphism of the toll-like receptor 2 (TLR2) gene and the Asp299Gly polymorphism of the TLR4 gene in critically ill patients affect their clinical outcomes. METHODS: Medical and surgical patients in three intensive care units (ICU) were enrolled in this prospective study. TLR2 and TLR4 gene polymorphisms were determined using restriction fragment length...

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Source

Identifiers

PMID: 24366499
DOI: 10.1177/0300060513504358

Genes

TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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