Article
Common variants of TLR1 associate with organ dysfunction and sustained pro-inflammatory responses during sepsis.
PloS one - 29 Oct 2010
Pino-Yanes Maria, Corrales Almudena, Casula Milena, Blanco Jesús, Muriel Arturo, Espinosa Elena, García-Bello Miguel, Torres Antoni, Ferrer Miguel, Zavala Elizabeth, Villar Jesús, Flores Carlos
Abstract excerpt
BACKGROUND: Toll-like receptors (TLRs) are critical components for host pathogen recognition and variants in genes participating in this response influence susceptibility to infections. Recently, TLR1 gene polymorphisms have been found correlated with whole blood hyper-inflammatory responses to pathogen-associated molecules and associated with sepsis-associated multiorgan dysfunction and acute lung injury (ALI)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.