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Article

Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.

American journal of respiratory and critical care medicine - 1 Oct 2008

Wurfel Mark M, Gordon Anthony C, Holden Tarah D, Radella Frank, Strout Jeanna, Kajikawa Osamu, Ruzinski John T, Rona Gail, Black R Anthony, Stratton Seth, Jarvik Gail P, Hajjar Adeline M, Nickerson Deborah A, Rieder Mark, Sevransky Jonathan, Maloney James P, Moss Marc, Martin Greg, Shanholtz Carl, Garcia Joe G N, Gao Li, Brower Roy, Barnes Kathleen C, Walley Keith R, Russell James A, Martin Thomas R

Abstract excerpt

RATIONALE: Polymorphisms affecting Toll-like receptor (TLR)-mediated responses could predispose to excessive inflammation during an infection and contribute to an increased risk for poor outcomes in patients with sepsis. OBJECTIVES: To identify hypermorphic polymorphisms causing elevated TLR-medi...

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Source

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Identifiers

PMID: 18635889
DOI: 10.1164/rccm.200803-462OC
PMCID: PMC2556453

Genes

TLR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18635889-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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