TLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis.

doi:10.1016/j.cmi.2016.08.028

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Article

TLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Jan 2017

Chantratita N, Tandhavanant S, Seal S, Wikraiphat C, Wongsuvan G, Ariyaprasert P, Suntornsut P, Teerawattanasook N, Jutrakul Y, Srisurat N, Chaimanee P, Mahavanakul W, Srisamang P, Phiphitaporn S, Mokchai M, Anukunananchai J, Wongratanacheewin S, Chetchotisakd P, Emond M J, Peacock S J, West T E

Abstract excerpt

OBJECTIVES: To identify important pathogen recognition receptor (PRR) pathways regulating innate immune responses and outcome in Staphylococcus aureus sepsis. METHODS: We analysed whether candidate PRR pathway genetic variants were associated with killed S. aureus-induced cytokine responses ex vivo and performed follow-up in vitro studies. We tested the association of our top-ranked variant with cytokine...

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PMID: 27615723
DOI: 10.1016/j.cmi.2016.08.028
PMCID: PMC5218870

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TLR4
TNF

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