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Article

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.

Nature genetics - 1 Jul 2010

Zhu Hao, Shah Samar, Shyh-Chang Ng, Shinoda Gen, Einhorn William S, Viswanathan Srinivas R, Takeuchi Ayumu, Grasemann Corinna, Rinn John L, Lopez Mary F, Hirschhorn Joel N, Palmert Mark R, Daley George Q

Abstract excerpt

Recently, genome-wide association studies have implicated the human LIN28B locus in regulating height and the timing of menarche. LIN28B and its homolog LIN28A are functionally redundant RNA-binding proteins that block biogenesis of let-7 microRNAs. lin-28 and let-7 were discovered in Caenorhabdi...

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Identifiers

PMID: 20512147
DOI: 10.1038/ng.593
PMCID: PMC3069638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20512147-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.PMID 20512147Read ↗

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