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Impact of Growth Hormone-Related Mutations on Mammalian Aging

27 Nov 2018

Abstract excerpt

Mutations of a single gene can lead to a major increase in longevity in organisms ranging from yeast and worms to insects and mammals. Discovering these mutations (sometimes referred to as "longevity genes") led to identification of evolutionarily conserved molecular, cellular, and organismal mechanisms of aging. Studies in mice provided evidence for the important role of growth hormone (GH) signaling in...

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PMID: 30542372
DOI: 10.3389/fgene.2018.00586

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