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Article

Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2.

PLoS genetics - 1 Aug 2015

Madison Blair B, Jeganathan Arjun N, Mizuno Rei, Winslow Monte M, Castells Antoni, Cuatrecasas Miriam, Rustgi Anil K

Abstract excerpt

Let-7 miRNAs comprise one of the largest and most highly expressed family of miRNAs among vertebrates, and is critical for promoting differentiation, regulating metabolism, inhibiting cellular proliferation, and repressing carcinogenesis in a variety of tissues. The large size of the Let-7 family of miRNAs has complicated the development of mutant animal models. Here we describe the comprehensive repression of...

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Identifiers

PMID: 26244988
DOI: 10.1371/journal.pgen.1005408
PMCID: PMC4526516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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