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Article

A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1).

Cellular and molecular life sciences : CMLS - 30 Mar 2023

Heidary Somayyeh, Awasthi Nagendra, Page Nicole, Allnutt Theo, Lewis Rowena S, Liongue Clifford, Ward Alister C

Abstract excerpt

Signal transducer and activator of transcription (STAT) proteins act downstream of cytokine receptors to facilitate changes in gene expression that impact a range of developmental and homeostatic processes. Patients harbouring loss-of-function (LOF) STAT5B mutations exhibit postnatal growth failure due to lack of responsiveness to growth hormone as well as immune perturbation, a disorder called growth hormone...

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Identifiers

PMID: 36995466
DOI: 10.1007/s00018-023-04759-y
PMCID: PMC10063521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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