Article
Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs.
American journal of physiology. Endocrinology and metabolism - 1 Jan 2005
Gagliardi Anthony D, Kuo Evan Y W, Raulic Sanda, Wagner Graham F, DiMattia Gabriel E
Abstract excerpt
Stanniocalcin (STC)-2 was discovered by its primary amino acid sequence identity to the hormone STC-1. The function of STC-2 has not been examined; thus we generated two lines of transgenic mice overexpressing human (h)STC-2 to gain insight into its potential functions through identification of overt phenotypes. Analysis of mouse Stc2 gene expression indicates that, unlike Stc1, it is not highly expressed during...
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