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Article

Mitochondrial DNA Damage as a Potential Mechanism for Age-Related Macular Degeneration

26 May 2010

Abstract excerpt

PURPOSE: Increasing evidence suggests a central role for mitochondrial (mt) dysfunction in age-related macular degeneration (AMD). Previous proteomic data from the retinal pigment epithelium (RPE) revealed significant changes to mt proteins, suggesting potential functional defects and damage to mitochondrial DNA (mtDNA) with AMD progression. The present study tests the hypothesis that mtDNA damage increases with...

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PMID: 20505194
DOI: 10.1167/iovs.10-5429

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