Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low frequency mitochondrial DNA heteroplasmy SNPs in blood, retina, and [RPE+choroid] of age-related macular degeneration subjects.

PloS one - 1 Jan 2021

Atilano Shari R, Udar Nitin, Satalich Timothy A, Udar Viraat, Chwa Marilyn, Kenney M Cristina

Abstract excerpt

PURPOSE: Mitochondrial (mt) DNA damage is associated with age-related macular degeneration (AMD) and other human aging diseases. This study was designed to quantify and characterize mtDNA low-frequency heteroplasmy single nucleotide polymorphisms (SNPs) of three different tissues isolated from AMD subjects using Next Generation Sequencing (NGS) technology. METHODS: DNA was extracted from neural retina,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Choroid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Heteroplasmy

Share to Macular Degeneration

Share to Mitochondria

Share to Polymorphism, Single Nucleotide

Share to Retina

Source

Open in PubMed Open full text

Identifiers

PMID: 33513185
DOI: 10.1371/journal.pone.0246114
PMCID: PMC7846006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low frequency mitochondrial DNA heteroplasmy SNPs in blood, retina, and [RPE+choroid] of age-related macular degeneration subjects.PMID 33513185Read ↗

Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patients.Semantic proximity Read ↗

Mitochondrial DNA haplogroups associated with age-related macular degeneration.Semantic proximity Read ↗

Mitochondrial DNA Damage as a Potential Mechanism for Age-Related Macular DegenerationSemantic proximity Read ↗

Systemic Evidence for Mitochondrial Dysfunction in Age-Related Macular Degeneration as Revealed by mtDNA Copy Number Measurements in Peripheral BloodSemantic proximity Read ↗

Investigating Mitochondria as a Target for Treating Age-Related Macular DegenerationSemantic proximity Read ↗

Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration.Semantic proximity Read ↗

Deep sequencing of the mitochondrial genome reveals common heteroplasmic sites in NADH dehydrogenase genes.Semantic proximity Read ↗

Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration.Semantic proximity Read ↗

Multimodal single-cell analysis of non-random heteroplasmy distribution in human retinal mitochondrial diseaseSemantic proximity Read ↗

Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study.Semantic proximity Read ↗

The ability of human nuclear DNA to cause false positive low-abundance heteroplasmy calls varies across the mitochondrial genomeSemantic proximity Read ↗

Pathogenic mitochondrial genome variation, heteroplasmy thresholding and mitochondrial constraint measures in a healthy older cohortSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.