Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration.

Investigative ophthalmology & visual science - 1 Jun 2011

Lin Haijiang, Xu Haifeng, Liang Fong-Qi, Liang Hao, Gupta Praveena, Havey Anna N, Boulton Michael E, Godley Bernard F

Abstract excerpt

PURPOSE: Mitochondrial DNA (mtDNA) damage may be associated with age-related diseases, such as age-related macular degeneration (AMD). The present study was designed to test whether the frequency of mtDNA damage, heteroplasmic mtDNA mutations, and repair capacity correlate with progression of AMD. METHODS: Macular and peripheral RPE cells were isolated and cultured from human donor eyes with and without AMD. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Glycosylases

Share to DNA Repair

Share to Hydrogen Peroxide

Share to Macular Degeneration

Share to Retinal Pigment Epithelium

Share to Tissue Donors

Source

Open in PubMed Open full text

Identifiers

PMID: 21273542
DOI: 10.1167/iovs.10-6163
PMCID: PMC3109040

Genes

RPE
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration.PMID 21273542Read ↗

Mitochondrial DNA Damage as a Potential Mechanism for Age-Related Macular DegenerationSemantic proximity Read ↗

Investigating Mitochondria as a Target for Treating Age-Related Macular DegenerationSemantic proximity Read ↗

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD)Semantic proximity Read ↗

Mitochondrial and Nuclear DNA Damage and Repair in Age-Related Macular DegenerationSemantic proximity Read ↗

Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatmentSemantic proximity Read ↗

Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degenerationSemantic proximity Read ↗

PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD PathogenesisSemantic proximity Read ↗

Mitochondrial Dysfunction in Retinal DiseasesSemantic proximity Read ↗

Oxidation and age-related macular degeneration: insights from molecular biologySemantic proximity Read ↗

Systemic Evidence for Mitochondrial Dysfunction in Age-Related Macular Degeneration as Revealed by mtDNA Copy Number Measurements in Peripheral BloodSemantic proximity Read ↗

Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration.Semantic proximity Read ↗

Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.