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Article

Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration.

Experimental eye research - 1 Apr 2016

Ferrington Deborah A, Kapphahn Rebecca J, Leary Michaela M, Atilano Shari R, Terluk Marcia R, Karunadharma Pabalu, Chen George Kuei-Jie, Ratnapriya Rinki, Swaroop Anand, Montezuma Sandra R, Kenney M Cristina

Abstract excerpt

Age-related macular degeneration (AMD) is a major cause of blindness among the elderly in the developed world. Genetic analysis of AMD has identified 34 high-risk loci associated with AMD. The genes at these high risk loci belong to diverse biological pathways, suggesting different mechanisms leading to AMD pathogenesis. Thus, therapies targeting a single pathway for all AMD patients will likely not be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26854823
DOI: 10.1016/j.exer.2016.01.018
PMCID: PMC4842097

Genes

CFH
RPE
CETP
APOE
ARMS2
LIPC
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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