Article
Comparisons of CYP2A6 genotype and enzyme activity between Swedes and Koreans.
Drug metabolism and pharmacokinetics - 1 Jan 2013
Djordjevic Natasa, Carrillo Juan Antonio, van den Broek Marieke P J, Kishikawa Junko, Roh Hyung-Keun, Bertilsson Leif, Aklillu Eleni
Abstract excerpt
The aim was to compare cytochrome P450 2A6 (CYP2A6) genotype and enzyme activity between Swedes and Koreans, and to investigate the influence of genotype, sex, age, cigarette smoking and oral contraceptive (OC) use on enzyme activity. The study involved 190 Swedes and 144 Koreans. Genotyping for CYP2A6*1B, *1×2, *4, *5, *7, *8, *9, *10, *18 and *19 alleles was done. Using caffeine as a probe, in vivo CYP2A6...
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