Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired Glutamate Transport in a Mouse Model of Tau Pathology in Astrocytes

11 Jan 2006

Abstract excerpt

Filamentous tau inclusions in neurons and glia are neuropathological hallmarks of tauopathies. The discovery of microtubule-associated protein tau gene mutations that are pathogenic for a heterogenous group of neurodegenerative disorders, called frontotemporal dementia and parkinsonism linked to chromosome-17 (FTDP-17), directly implicate tau abnormalities in the onset/progression of disease. Although the role of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16407562
DOI: 10.1523/jneurosci.3861-05.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired Glutamate Transport in a Mouse Model of Tau Pathology in AstrocytesPMID 16407562Read ↗

Transgenic Mouse Model of Tau Pathology in Astrocytes Leading to Nervous System DegenerationSemantic proximity Read ↗

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.Semantic proximity Read ↗

Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression.Semantic proximity Read ↗

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.Semantic proximity Read ↗

Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild TBI without appreciable changes in tauopathy.Semantic proximity Read ↗

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.Semantic proximity Read ↗

Axonal Degeneration Induced by Targeted Expression of Mutant Human Tau in Oligodendrocytes of Transgenic Mice That Model Glial TauopathiesSemantic proximity Read ↗

Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.Semantic proximity Read ↗

Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.Semantic proximity Read ↗

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats.Semantic proximity Read ↗

Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau.Semantic proximity Read ↗

Transgenic mouse models of tauopathies: prospects for animal models of Pick's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.