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Article

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell‐type‐specific

12 Sept 2016

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder that is caused by a CAG expansion in the Huntingtin (HTT) gene, leading to HTT inclusion formation in the brain. The mutant huntingtin protein (mHTT) is ubiquitously expressed and therefore nuclear inclusions could be present in all brain cells. The effects of nuclear inclusion formation have been mainly studied in neurons,...

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PMID: 27615381
DOI: 10.1002/glia.23050

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