Article
The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer.
Biochemical and biophysical research communications - 21 May 2010
Farnebo Marianne, Bykov Vladimir J N, Wiman Klas G
Abstract excerpt
The tumor suppressor p53 has been implicated in a growing number of biological processes, including cell cycle arrest, senescence, apoptosis, autophagy, metabolism, and aging. Activation of p53 in response to oncogenic stress eliminates nascent tumor cells by apoptosis or senescence. p53 is regulated at the protein level by posttranslational modifications such as phosphorylation and acetylation. A p53 antisense...
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