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Article

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.

Annual review of biochemistry - 2 Jun 2016

Joerger Andreas C, Fersht Alan R

Abstract excerpt

Inactivation of the transcription factor p53, through either direct mutation or aberrations in one of its many regulatory pathways, is a hallmark of virtually every tumor. In recent years, screening for p53 activators and a better understanding of the molecular mechanisms of oncogenic perturbations of p53 function have opened up a host of novel avenues for therapeutic intervention in cancer: from the...

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Identifiers

PMID: 27145840
DOI: 10.1146/annurev-biochem-060815-014710

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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