Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies.

doi:10.1093/jnci/88.20.1442

Back to search

Article

Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies.

Journal of the National Cancer Institute - 16 Oct 1996

Harris C C

Abstract excerpt

The p53 tumor suppressor protein is involved in multiple central cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle control, and apoptosis. p53 is functionally inactivated by structural mutations, interaction with viral products, and endogenous cell...

Topics

Animals
Apoptosis
Combined Modality Therapy
DNA Damage
DNA, Neoplasm
Genes, p53
Genetic Therapy
Humans
Immunotherapy
Mutation
Neoplasms
Phosphorylation
Structure-Activity Relationship
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.