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Article

Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting.

Biochimica et biophysica acta. Reviews on cancer - 1 Aug 2021

Hernández Borrero Liz J, El-Deiry Wafik S

Abstract excerpt

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response network with multiple diverse inputs and downstream outputs relevant to its role as a tumor suppressor pathway. While inroads...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33932560
DOI: 10.1016/j.bbcan.2021.188556
PMCID: PMC8730328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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