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Article

DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach.

BMC gastroenterology - 28 Mar 2014

Loh Marie, Liem Natalia, Vaithilingam Aparna, Lim Pei Li, Sapari Nur Sabrina, Elahi Eiram, Mok Zuan Yu, Cheng Chee Leong, Yan Benedict, Pang Brendan, Salto-Tellez Manuel, Yong Wei Peng, Iacopetta Barry, Soong Richie

Abstract excerpt

BACKGROUND: Methylation-induced silencing of promoter CpG islands in tumor suppressor genes plays an important role in human carcinogenesis. In colorectal cancer, the CpG island methylator phenotype (CIMP) is defined as widespread and elevated levels of DNA methylation and CIMP+ tumors have distinctive clinicopathological and molecular features. In contrast, the existence of a comparable CIMP subtype in gastric...

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Identifiers

PMID: 24674026
DOI: 10.1186/1471-230X-14-55
PMCID: PMC3986689

Genes

BRAF
HOXA5
KRAS

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Source receipt: pubmed, retrieved 7 Sept 2026.

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