Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphatase of regenerating liver-1 promotes cell migration and invasion and regulates filamentous actin dynamics.

The Journal of pharmacology and experimental therapeutics - 1 Aug 2010

Nakashima Masanao, Lazo John S

Abstract excerpt

The phosphatases of regenerating liver (PRLs) are a unique family of plasma membrane-associated protein tyrosine phosphatases that have been hypothesized to be involved in metastatic cancer. How PRLs control cancer cell migration, invasion, and proliferation remains largely unknown. In the current study, we demonstrate a role for PRL-1 in the regulation of filamentous actin dynamics, which could promote cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Actins
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Movement

Share to Neoplasm Invasiveness

Share to Protein Tyrosine Phosphatases

Share to rho-Associated Kinases

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 20484558
DOI: 10.1124/jpet.110.167809
PMCID: PMC2913768

Genes

PRL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphatase of regenerating liver-1 promotes cell migration and invasion and regulates filamentous actin dynamics.PMID 20484558Read ↗

Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.Semantic proximity Read ↗

Phosphatase of regenerating liver: a novel target for cancer therapySemantic proximity Read ↗

PRL phosphatases as potential molecular targets in cancerSemantic proximity Read ↗

Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition.Semantic proximity Read ↗

Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2.Semantic proximity Read ↗

Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.Semantic proximity Read ↗

The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides.Semantic proximity Read ↗

Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression.Semantic proximity Read ↗

DLC‐1:a Rho GTPase‐activating protein and tumour suppressorSemantic proximity Read ↗

PRL-3 promotes telomere deprotection and chromosomal instabilitySemantic proximity Read ↗

Upregulated LASP-1 correlates with a malignant phenotype and its potential therapeutic role in human cholangiocarcinoma.Semantic proximity Read ↗

Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL PhosphataseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.