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Article

Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2.

Life sciences - 2 Jan 2010

Min Sang-Hyun, Kim Dong Min, Heo Young-Shin, Kim Ho Min, Kim Il-Chul, Yoo Ook-Joon

Abstract excerpt

AIMS: The phosphatase of regenerating liver (PRL) family is related to tumorigenesis and metastasis in various cancer types. Its overexpression increases cell motility and proliferation via the downregulation of p21 expression. In a previous study, we reported that PRL-1 downregulates p53 and is...

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Source

Identifiers

PMID: 19945467
DOI: 10.1016/j.lfs.2009.11.010

Genes

PRL
MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19945467-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2.PMID 19945467Read ↗

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PRL phosphatases as potential molecular targets in cancerSemantic proximity Read ↗

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Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.Semantic proximity Read ↗

Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition.Semantic proximity Read ↗

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The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides.Semantic proximity Read ↗

Rictor mediates p53 deactivation to facilitate the malignant transformation of hepatocytes and promote hepatocarcinogenesisSemantic proximity Read ↗

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