Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides.

Biochemistry - 6 Sept 2011

McParland Victoria, Varsano Giulia, Li Xun, Thornton Janet, Baby Jancy, Aravind Ajay, Meyer Christoph, Pavic Karolina, Rios Pablo, Köhn Maja

Abstract excerpt

Phosphatase of regenerating liver 3 (PRL-3) is suggested as a biomarker and therapeutic target in several cancers. It has a well-established causative role in cancer metastasis. However, little is known about its natural substrates, pathways, and biological functions, and only a few protein substrates have been suggested so far. To improve our understanding of the substrate specificity and molecular determinants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Cysteine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Neoplasm Invasiveness

Share to Phosphatidylinositols

Share to Protein Tyrosine Phosphatases

Share to Serine

Share to Substrate Specificity

Source

Identifiers

PMID: 21806020
DOI: 10.1021/bi201095z

Genes

PRL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides.PMID 21806020Read ↗

PRL phosphatases as potential molecular targets in cancerSemantic proximity Read ↗

PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth.Semantic proximity Read ↗

Phosphatase of regenerating liver: a novel target for cancer therapySemantic proximity Read ↗

Phosphatase of regenerating liver-1 promotes cell migration and invasion and regulates filamentous actin dynamics.Semantic proximity Read ↗

Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL PhosphataseSemantic proximity Read ↗

Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition.Semantic proximity Read ↗

Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression.Semantic proximity Read ↗

A Review of Phosphocreatine 3 Kinase δ Subtype (PI3Kδ) and Its Inhibitors in Malignancy.Semantic proximity Read ↗

Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.Semantic proximity Read ↗

Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2.Semantic proximity Read ↗

Physiological and oncogenic roles of the PRL phosphatasesSemantic proximity Read ↗

Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.