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Article

Upregulated LASP-1 correlates with a malignant phenotype and its potential therapeutic role in human cholangiocarcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jun 2016

Zhang Hongchen, Li Zhizhen, Chu Bingfeng, Zhang Fei, Zhang Yijian, Ke Fayong, Chen Yuanyuan, Xu Yi, Liu Shibo, Zhao Shuai, Liang Haibin, Weng Mingzhe, Wu Xiangsong, Li Maolan, Wu Wenguang, Quan Zhiwei, Liu Yingbin, Zhang Yong, Gong Wei

Abstract excerpt

LIM and SH3 protein 1 (LASP-1) is demonstrated to play a key role in occurrence and development of tumors. However, the expression and function of LASP-1 in cholangiocarcinoma (CCA) remain largely unexplored. This study aimed to investigate the effect of regulated LASP-1 expression on migration, invasion, proliferation, and apoptosis of CCA cells and on tumorigenesis in vivo, and to examine clinico-oncological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26729195
DOI: 10.1007/s13277-015-4704-4

Genes

CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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