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Article

PRL-3 promotes telomere deprotection and chromosomal instability

26 Apr 2017

Abstract excerpt

Phosphatase of regenerating liver (PRL-3) promotes cell invasiveness, but its role in genomic integrity remains unknown. We report here that shelterin component RAP1 mediates association between PRL-3 and TRF2. In addition, TRF2 and RAP1 assist recruitment of PRL-3 to telomeric DNA. Silencing of PRL-3 in colon cancer cells does not affect telomere integrity or chromosomal stability, but induces reactive oxygen...

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Share to Genetics, Aging, and Longevity in Model Organisms
Share to Protein Tyrosine Phosphatases
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28482095
DOI: 10.1093/nar/gkx392

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