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Article

Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression.

International journal of cancer - 15 Apr 2009

Mizuuchi Eri, Semba Shuho, Kodama Yoshinori, Yokozaki Hiroshi

Abstract excerpt

Phosphatase of regenerating liver-3 (PRL-3) is a member of the PRL protein tyrosine phosphatase family and has been proposed to promote the invasiveness and metastastic capability of colorectal cancers (CRCs); however, the underlying mechanisms and target molecules of PRL-3 protein remain unknown. On the basis of the biological significance of PRL-3 phosphatase activity confirmed by the catalytically inactive...

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Source

Identifiers

PMID: 19115206
DOI: 10.1002/ijc.24111

Genes

PRL
KRT8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression.PMID 19115206Read ↗

PRL phosphatases as potential molecular targets in cancerSemantic proximity Read ↗

Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.Semantic proximity Read ↗

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The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides.Semantic proximity Read ↗

Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal OncogenesisSemantic proximity Read ↗

PRL-3 promotes telomere deprotection and chromosomal instabilitySemantic proximity Read ↗

Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion.Semantic proximity Read ↗

MMP7 Is Required to Mediate Cell Invasion and Tumor Formation upon Plakophilin3 LossSemantic proximity Read ↗

Phosphatase of regenerating liver: a novel target for cancer therapySemantic proximity Read ↗

Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2.Semantic proximity Read ↗

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